St.Luke's-Roosevelt Hospital has been involved with the earliest research in cardiac surgery and performed the first open-heart surgical procedure in New York State in 1954
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Research performed on early techniques of cardiac bypass as well organ perfusion systems for renal transplant was performed in the St. Luke's laboratory
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Although the Sisters of the Episcopal Church of the Holy Communion originally took charge of the nursing in the hospital, a shortage of adequately trained nurses available led to the formal creation of the nursing school in 1888
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